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Multiple Choice

Which urine pH condition favors struvite stone formation?

Alkaline urine favors struvite stone formation. Struvite is magnesium ammonium phosphate and tends to precipitate when urine pH is high. This alkaline environment is often created by infections with urease-producing bacteria (for example, Proteus, Klebsiella) that split urea into ammonia, raising the urine pH. As the pH increases, these salts crystallize and can build into stones, sometimes forming large, branching “staghorn” calculi. In acidic urine, struvite formation is less likely, with other stone types like uric acid or calcium oxalate more common. Neutral urine isn’t particularly conducive to struvite precipitation.

Alkaline urine favors struvite stone formation. Struvite is magnesium ammonium phosphate and tends to precipitate when urine pH is high. This alkaline environment is often created by infections with urease-producing bacteria (for example, Proteus, Klebsiella) that split urea into ammonia, raising the urine pH. As the pH increases, these salts crystallize and can build into stones, sometimes forming large, branching “staghorn” calculi. In acidic urine, struvite formation is less likely, with other stone types like uric acid or calcium oxalate more common. Neutral urine isn’t particularly conducive to struvite precipitation.